Hexamethylquercetagetin (Hexa-O-methylquercetagetin, Quercetagetin hexamethyl ether, 3,5,6,7,3,4-Hexamethoxyflavone) is an orally active NF-kappaB inhibitor. Hexamethylquercetagetin inhibits NF-kappaB-derived luciferase activity, reduces phosphorylated p65 and IkappaBalpha, Cyclin D1, Bcl-2 and blocks TNFalpha-induced NF-kappaB activation. Hexamethylquercetagetin inhibits survival and proliferation of cervical carcinoma cells. Hexamethylquercetagetin suppresses tumor volume and weight in BALB/c nude mouse xenograft models of cervical carcinoma. Hexamethylquercetagetin can be used for the research of cancer, such as cervical carcinoma[1][2].
Molekulargewicht:
402.39
Reinheit:
98
CAS Nummer:
[1251-84-9]
Formel:
C21H22O8
Target-Kategorie:
Bcl-2 Family,IKK,NF-kappaB
Anwendungsbeschreibung:
MCE Product type: Natural Products
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