Hexamethylquercetagetin (Hexa-O-methylquercetagetin, Quercetagetin hexamethyl ether, 3,5,6,7,3,4-Hexamethoxyflavone) is an orally active NF-kappaB inhibitor. Hexamethylquercetagetin inhibits NF-kappaB-derived luciferase activity, reduces phosphorylated p65 and IkappaBalpha, Cyclin D1, Bcl-2 and blocks TNFalpha-induced NF-kappaB activation. Hexamethylquercetagetin inhibits survival and proliferation of cervical carcinoma cells. Hexamethylquercetagetin suppresses tumor volume and weight in BALB/c nude mouse xenograft models of cervical carcinoma. Hexamethylquercetagetin can be used for the research of cancer, such as cervical carcinoma[1][2].
Molecular Weight:
402.39
Purity:
98
CAS Number:
[1251-84-9]
Formula:
C21H22O8
Target:
Bcl-2 Family,IKK,NF-kappaB
Application Notes:
MCE Product type: Natural Products
* VAT and and shipping costs not included. Errors and price changes excepted
