Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-kappaB inhibitor with an IC50 value of 0.5 µM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-kappaB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394)[1][2][3].
Molekulargewicht:
348.39
Reinheit:
98.99
CAS Nummer:
[23062-24-0]
Formel:
C19H24O6
Target-Kategorie:
Akt,Apoptosis,Bcl-2 Family,NF-kappaB
Anwendungsbeschreibung:
MCE Product type: Natural Products
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