Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-kappaB inhibitor with an IC50 value of 0.5 µM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-kappaB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394)[1][2][3].
Molecular Weight:
348.39
Purity:
99.74
CAS Number:
[23062-24-0]
Formula:
C19H24O6
Target:
Akt,Apoptosis,Bcl-2 Family,NF-kappaB
Application Notes:
MCE Product type: Natural Products
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