Silybin B (Silibinin B) is an orally active amyloid-beta aggregation inhibitor and ATR pathway activator that can cross the blood-brain barrier. Silybin B inhibits Abeta fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimers disease and Cisplatin chemotherapy-related neurotoxicity[1][2][3].
Molekulargewicht:
482.44
Reinheit:
99.90
CAS Nummer:
[142797-34-0]
Formel:
C25H22O10
Target-Kategorie:
Amyloid-beta,Apoptosis,JNK,p38 MAPK
Anwendungsbeschreibung:
MCE Product type: Natural Products
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
