Silybin B (Silibinin B) is an orally active amyloid-beta aggregation inhibitor and ATR pathway activator that can cross the blood-brain barrier. Silybin B inhibits Abeta fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimers disease and Cisplatin chemotherapy-related neurotoxicity[1][2][3].
Molecular Weight:
482.44
Purity:
99.90
CAS Number:
[142797-34-0]
Formula:
C25H22O10
Target:
Amyloid-beta,Apoptosis,JNK,p38 MAPK
Application Notes:
MCE Product type: Natural Products
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