Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.
Molekulargewicht:
6554.54 (free acid)
Reinheit:
95.72
Formel:
C272H429N85O84S10.xC2HF3O2
Target-Kategorie:
Sodium Channel
Anwendungsbeschreibung:
MCE Product type: Peptides
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