Peptide P60 is a FOXP3 inhibitor. Peptide P60 can enter cells, inhibit the nuclear translocation of FOXP3, and diminish its ability to suppress the transcription factors NF-kappaB and NFAT. Peptide P60 can inhibit the immunosuppressive activity of regulatory T cells (Treg) derived from mice and humans, and enhance the stimulation of effector T cells in vitro. Peptide P60 can induce a lymphoproliferative autoimmune syndrome with pathological manifestations resembling those reported in scurfy mice lacking functional Foxp3. Peptide P60 can enhance the immunogenicity of cancer and viral vaccines.[1]
Molekulargewicht:
1994.34
Reinheit:
98.39
CAS Nummer:
[1319725-20-6]
Formel:
C95H132N24O20S2
Target-Kategorie:
NF-kappaB,Nuclear Factor of activated T Cells (NFAT)
Anwendungsbeschreibung:
Peptides
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
