Peptide P60 is a FOXP3 inhibitor. Peptide P60 can enter cells, inhibit the nuclear translocation of FOXP3, and diminish its ability to suppress the transcription factors NF-kappaB and NFAT. Peptide P60 can inhibit the immunosuppressive activity of regulatory T cells (Treg) derived from mice and humans, and enhance the stimulation of effector T cells in vitro. Peptide P60 can induce a lymphoproliferative autoimmune syndrome with pathological manifestations resembling those reported in scurfy mice lacking functional Foxp3. Peptide P60 can enhance the immunogenicity of cancer and viral vaccines.[1]
Molecular Weight:
1994.34
Purity:
98.39
CAS Number:
[1319725-20-6]
Formula:
C95H132N24O20S2
Target:
NF-kappaB,Nuclear Factor of activated T Cells (NFAT)
Application Notes:
Peptides
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