TRV055 (TRV120055) (hydrochloride) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and alpha-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Galphaq-mediated signaling pathways, upregulates TGF-beta1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses[1][2].
Molekulargewicht:
868.42
Reinheit:
98.88
Formel:
C42H58ClN9O9
Target-Kategorie:
Angiotensin Receptor
Anwendungsbeschreibung:
MCE Product type: Peptides
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
