TRV055 (TRV120055) (hydrochloride) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and alpha-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Galphaq-mediated signaling pathways, upregulates TGF-beta1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses[1][2].
Molecular Weight:
868.42
Purity:
98.88
Formula:
C42H58ClN9O9
Target:
Angiotensin Receptor
Application Notes:
MCE Product type: Peptides
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