TGF beta 1/TGFB1 LAP, Human (Biotinylated, HEK293, His-Avi)

Produktübersicht

• Artikelname: TGF beta 1/TGFB1 LAP, Human (Biotinylated, HEK293, His-Avi)
• Artikelnummer: MCE-HY-P78168
• Hersteller Artikelnummer: HY-P78168
• Alternativnummer: MCE-HY-P78168-20UG,MCE-HY-P78168-50UG
• Hersteller: MedchemExpress
• Kategorie: Proteine/Peptide
• Alternative Synonym: TGF beta 1/TGFB1 LAP Protein, Human (Biotinylated, HEK293, His-Avi),Human,HEK293

Produktbeschreibung

The latency-associated peptide (LAP) of the transforming growth factor beta-1 (TGF-beta-1) proprotein is an important precursor that forms a complex with TGF-beta-1. LAP maintains the latent state of TGF-beta-1 during storage in the extracellular matrix, ensuring controlled activation. Interactions with ''environmental molecules such as LTBP1, LRRC32/GARP, and LRRC33/NRROS intricately regulate TGF-beta-1 activation. LRRC33/NRROS influences the activation of macrophages and microglia, while LRRC32/GARP controls the activation of activated regulatory T cells. Interactions with integrins induce conformational changes in LAP, releasing active TGF-beta-1. LAP orchestrates controlled TGF-beta-1 activation in different physiological contexts. Recombinant human TGF beta 1/TGFB1 LAP (biotinylated, expressed in HEK293 cells, Avi-tagged) is a biotinylated, Avi-tagged LAP protein expressed in HEK293 cells[1][2].

Produkteigenschaften

• Molekulargewicht: Approximately 45-50 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
• Reinheit: 95.00
• Formel: 7040(Gene_ID)P01137 (L30-R278, C33S)(Accession)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Recombinant Proteins