TGF beta 1/TGFB1 LAP, Human (Biotinylated, HEK293, His-Avi)
Biozol Catalog Number:
MCE-HY-P78168
Supplier Catalog Number:
HY-P78168
Alternative Catalog Number:
MCE-HY-P78168-20UG,MCE-HY-P78168-50UG
Manufacturer:
MedchemExpress
Category:
Proteine/Peptide
Alternative Names:
TGF beta 1/TGFB1 LAP Protein, Human (Biotinylated, HEK293, His-Avi),Human,HEK293
The latency-associated peptide (LAP) of the transforming growth factor beta-1 (TGF-beta-1) proprotein is an important precursor that forms a complex with TGF-beta-1. LAP maintains the latent state of TGF-beta-1 during storage in the extracellular matrix, ensuring controlled activation. Interactions with ''environmental molecules such as LTBP1, LRRC32/GARP, and LRRC33/NRROS intricately regulate TGF-beta-1 activation. LRRC33/NRROS influences the activation of macrophages and microglia, while LRRC32/GARP controls the activation of activated regulatory T cells. Interactions with integrins induce conformational changes in LAP, releasing active TGF-beta-1. LAP orchestrates controlled TGF-beta-1 activation in different physiological contexts. Recombinant human TGF beta 1/TGFB1 LAP (biotinylated, expressed in HEK293 cells, Avi-tagged) is a biotinylated, Avi-tagged LAP protein expressed in HEK293 cells[1][2].
Molecular Weight:
Approximately 45-50 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Purity:
95.00
Formula:
7040(Gene_ID)P01137 (L30-R278, C33S)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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