Fresolimumab (GC1008) is a human monoclonal antibody against TGF-beta that neutralizes all mammalian active subtypes of TGF-beta. The binding affinity of Fresolimumab to TGF-beta2 is 1.8 nM. Fresolimumab improves Bleomycin (HY-108345)-induced acute lung injury. Fresolimumab radiolabeled with 89Zr can be used for PET analysis of TGF-beta expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease[1][2][3][4].
Molekulargewicht:
(144.4 kDa)
Reinheit:
99.51
CAS Nummer:
[948564-73-6]
Target-Kategorie:
TGF-beta/Smad
Anwendungsbeschreibung:
Inhibitory Antibodies
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