Anti-Human/Mouse LY6E Antibody (9B12) Preis auf Anfrage

Produktübersicht

• Artikelname: Anti-Human/Mouse LY6E Antibody (9B12) Preis auf Anfrage
• Artikelnummer: MCE-HY-P992056
• Hersteller Artikelnummer: HY-P992056
• Alternativnummer: MCE-HY-P992056-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Antikörper

Produktbeschreibung

Anti-Human/Mouse LY6E Antibody (9B12) is a high-affinity, multi-target antibody that binds specifically to LY6E. Anti-Human/Mouse LY6E Antibody (9B12) binds specifically to cell-surface LY6E and enters lysosomes via lipid raft-dependent endocytosis, thereby effectively inhibiting the growth of various LY6E-expressing solid tumors (such as breast cancer and lung cancer) in both in vitro and in vivo models. Anti-Human/Mouse LY6E Antibody (9B12) exerts a dual mechanism of action: on one hand, it blocks the interaction between PILRalpha and CD8alpha, specifically reduces the survival rate of peripheral CD8+ T cells and induces their activation, breaking the state of cellular quiescence, on the other hand, it recognizes and immunoprecipitates IDE under both non-denaturing and denaturing conditions, which is applicable to studies on the subcellular localization and protein interactions of IDE. The regulatory effect of Anti-Human/Mouse LY6E Antibody (9B12) on CD8+ T cells strictly depends on the presence of PILRalpha, and it does not affect CD4+ T cells or T cell development in the thymus, exhibiting high specificity[1][2][3].

Produkteigenschaften

• Target-Kategorie: Autophagy

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Inhibitory Antibodies