Anti-Human/Mouse LY6E Antibody (9B12) Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-P992056
Supplier Catalog Number:
HY-P992056
Alternative Catalog Number:
MCE-HY-P992056-1UNIT
Manufacturer:
MedchemExpress
Category:
Antikörper
Anti-Human/Mouse LY6E Antibody (9B12) is a high-affinity, multi-target antibody that binds specifically to LY6E. Anti-Human/Mouse LY6E Antibody (9B12) binds specifically to cell-surface LY6E and enters lysosomes via lipid raft-dependent endocytosis, thereby effectively inhibiting the growth of various LY6E-expressing solid tumors (such as breast cancer and lung cancer) in both in vitro and in vivo models. Anti-Human/Mouse LY6E Antibody (9B12) exerts a dual mechanism of action: on one hand, it blocks the interaction between PILRalpha and CD8alpha, specifically reduces the survival rate of peripheral CD8+ T cells and induces their activation, breaking the state of cellular quiescence, on the other hand, it recognizes and immunoprecipitates IDE under both non-denaturing and denaturing conditions, which is applicable to studies on the subcellular localization and protein interactions of IDE. The regulatory effect of Anti-Human/Mouse LY6E Antibody (9B12) on CD8+ T cells strictly depends on the presence of PILRalpha, and it does not affect CD4+ T cells or T cell development in the thymus, exhibiting high specificity[1][2][3].
Target:
Autophagy
Application Notes:
MCE Product type: Inhibitory Antibodies
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