Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 µM and 52.2 µM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity, 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions[1][2].
Molekulargewicht:
124.14
Reinheit:
99.96
CAS Nummer:
[95-71-6]
Formel:
C7H8O2
Target-Kategorie:
COX
Anwendungsbeschreibung:
MCE Product type: Natural Products
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