Inosine-5-diphosphate disodium (IDP disodium) is a decoy substrate of NM23-H2. Inosine-5-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 µM). Inosine-5-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of gamma-irradiation. Inosine-5-diphosphate disodium can be used for cancers like Burkitts lymphoma and cardiovascular diseases research[1][2][3].
Molekulargewicht:
428.19
Reinheit:
99.08
CAS Nummer:
[54735-61-4]
Formel:
C10H14N4O11P2
Target-Kategorie:
Apoptosis,c-Myc
Anwendungsbeschreibung:
MCE Product type: Reference compound
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