(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione, CAS [[69304-49-0]]

Produktübersicht

• Artikelname: (E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione, CAS [[69304-49-0]]
• Artikelnummer: MCE-HY-W014109
• Hersteller Artikelnummer: HY-W014109
• Alternativnummer: MCE-HY-W014109-10MG,MCE-HY-W014109-25MG,MCE-HY-W014109-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: (E)-5-(2-Bromovinyl)uracil, BVU

Produktbeschreibung

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time.

Produkteigenschaften

• Molekulargewicht: 217.02
• CAS Nummer: [69304-49-0]
• Formel: C6H5BrN2O2
• Target-Kategorie: DNA/RNA Synthesis

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1