(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time.
Molecular Weight:
217.02
CAS Number:
[69304-49-0]
Formula:
C6H5BrN2O2
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound1
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