2,4'-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4'-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-kappaB. 2,4'-Dihydroxybenzophenone is also a UV absorber[1][2].
Molekulargewicht:
214.22
Reinheit:
98.00
CAS Nummer:
[131-56-6]
Formel:
C13H10O3
Target-Kategorie:
IRAK,MyD88,NF-kappaB,Reactive Oxygen Species (ROS),Toll-like Receptor (TLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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