2,4'-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4'-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-kappaB. 2,4'-Dihydroxybenzophenone is also a UV absorber[1][2].
Molecular Weight:
214.22
Purity:
98.00
CAS Number:
[131-56-6]
Formula:
C13H10O3
Target:
IRAK,MyD88,NF-kappaB,Reactive Oxygen Species (ROS),Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted