2-(Bromomethyl)acrylic acid, CAS [[72707-66-5]]

Produktübersicht

• Artikelname: 2-(Bromomethyl)acrylic acid, CAS [[72707-66-5]]
• Artikelnummer: MCE-HY-W017180
• Hersteller Artikelnummer: HY-W017180
• Alternativnummer: MCE-HY-W017180-5G,MCE-HY-W017180-1G,MCE-HY-W017180-10G,MCE-HY-W017180-25G,MCE-HY-W017180-100MG,MCE-HY-W017180-250MG,MCE-HY-W017180-500MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: alpha-(Bromomethyl)acrylic acid, alpha-Methylated acrylamide, alpha-MAA

Produktbeschreibung

2-(Bromomethyl) acrylic acid is a Brutons tyrosine kinase (BTK) inhibitor. 2-(Bromomethyl) acrylic acid forms a covalent bond with the cysteine 481 (Cys481) residue of BTK via a nucleophilic addition-elimination reaction, thereby inhibiting the downstream B-cell receptor signaling pathway. 2-(Bromomethyl) acrylic acid induces immunogenic cell death in BTK-expressing B-cell lymphoma cells by releasing damage-associated molecular patterns including extracellular ATP and HMGB1. 2-(Bromomethyl) acrylic acid exhibits cytotoxicity against BTK-expressing B-cell lymphoma cells, but shows low toxicity to BTK-negative cells. 2-(Bromomethyl) acrylic acid can be used in studies related to B-cell lymphoma[1].

Produkteigenschaften

• Molekulargewicht: 164.99
• Reinheit: 98.26
• CAS Nummer: [72707-66-5]
• Formel: C4H5BrO2
• Target-Kategorie: Btk

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound