2-(Bromomethyl)acrylic acid, CAS [[72707-66-5]]

Product Overview

• Article Name: 2-(Bromomethyl)acrylic acid, CAS [[72707-66-5]]
• Biozol Catalog Number: MCE-HY-W017180
• Supplier Catalog Number: HY-W017180
• Alternative Catalog Number: MCE-HY-W017180-5G,MCE-HY-W017180-1G,MCE-HY-W017180-10G,MCE-HY-W017180-25G,MCE-HY-W017180-100MG,MCE-HY-W017180-250MG,MCE-HY-W017180-500MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: alpha-(Bromomethyl)acrylic acid, alpha-Methylated acrylamide, alpha-MAA

Product Description

2-(Bromomethyl) acrylic acid is a Brutons tyrosine kinase (BTK) inhibitor. 2-(Bromomethyl) acrylic acid forms a covalent bond with the cysteine 481 (Cys481) residue of BTK via a nucleophilic addition-elimination reaction, thereby inhibiting the downstream B-cell receptor signaling pathway. 2-(Bromomethyl) acrylic acid induces immunogenic cell death in BTK-expressing B-cell lymphoma cells by releasing damage-associated molecular patterns including extracellular ATP and HMGB1. 2-(Bromomethyl) acrylic acid exhibits cytotoxicity against BTK-expressing B-cell lymphoma cells, but shows low toxicity to BTK-negative cells. 2-(Bromomethyl) acrylic acid can be used in studies related to B-cell lymphoma[1].

Product Properties

• Molecular Weight: 164.99
• Purity: 98.26
• CAS Number: [72707-66-5]
• Formula: C4H5BrO2
• Target: Btk

Application Notes

• Application Notes: MCE Product type: Reference compound