iST2-1 is an Stimulation-2 (ST2) inhibitor with an IC50 value of 46.65 µM, blocks interaction between ST2 and IL-33, inhibits downstream signaling. iST2-1 functions as an immunomodulator, reduces proliferation of CD4+ and CD8+ T cells, increases regulatory T cell populations, reduces IFN-gamma+CD4+ T cell populations, increases Foxp3+CD4+ regulatory T cell populations in the gastrointestinal tract. iST2-1 reduces plasma soluble ST2 and IFN-gamma levels, reduces graft-versus-host disease scores, improves survival in graft-versus-host disease animal models, preserves graft-versus-tumor effect. iST2-1 can be used for the research of graft-versus-host disease[1][2].
Molekulargewicht:
378.42
Reinheit:
97.93
CAS Nummer:
[1019158-02-1]
Formel:
C22H22N2O4
Target-Kategorie:
Interleukin Related
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
