iST2-1 is an Stimulation-2 (ST2) inhibitor with an IC50 value of 46.65 µM, blocks interaction between ST2 and IL-33, inhibits downstream signaling. iST2-1 functions as an immunomodulator, reduces proliferation of CD4+ and CD8+ T cells, increases regulatory T cell populations, reduces IFN-gamma+CD4+ T cell populations, increases Foxp3+CD4+ regulatory T cell populations in the gastrointestinal tract. iST2-1 reduces plasma soluble ST2 and IFN-gamma levels, reduces graft-versus-host disease scores, improves survival in graft-versus-host disease animal models, preserves graft-versus-tumor effect. iST2-1 can be used for the research of graft-versus-host disease[1][2].
Molecular Weight:
378.42
Purity:
97.93
CAS Number:
[1019158-02-1]
Formula:
C22H22N2O4
Target:
Interleukin Related
Application Notes:
MCE Product type: Reference compound
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