N1-Acetyl-5-methoxykynuramine (hydrochloride), CAS [[1215711-91-3]]

Produktübersicht

• Artikelname: N1-Acetyl-5-methoxykynuramine (hydrochloride), CAS [[1215711-91-3]]
• Artikelnummer: MCE-HY-W587743
• Hersteller Artikelnummer: HY-W587743
• Alternativnummer: MCE-HY-W587743-5MG,MCE-HY-W587743-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: AMK (hydrochloride)

Produktbeschreibung

N1-Acetyl-5-methoxykynuramine (AMK) hydrochloride is an active metabolite of the neurohormone melatonin (HY-B0075). N1-Acetyl-5-methoxykynuramine hydrochloride (200 µM) effectively scavenges singlet oxygen (ROS).1 It also inhibits the production of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) induced by epinephrine and arachidonic acid in a concentration- and time-dependent manner, and suppresses the increase in COX-2 levels induced by LPS (HY-D1056) in RAW 264.7 macrophages at a concentration of 500 µM. In a mouse model of Parkinsons disease induced by MPTP (HY-15608), N1-Acetyl-5-methoxykynuramine hydrochloride (20 mg/kg) reduces the increase in lipid peroxidation in the cytosol and mitochondria of the substantia nigra and striatum. N1-Acetyl-5-methoxykynuramine hydrochloride can be used in research on metabolic and neurological diseases[1][2][3][4][5][6]

Produkteigenschaften

• Molekulargewicht: 272.73
• CAS Nummer: [1215711-91-3]
• Formel: C12H17ClN2O3
• Target-Kategorie: COX,PGE synthase,Prostaglandin Receptor,Reactive Oxygen Species (ROS)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound