N1-Acetyl-5-methoxykynuramine (hydrochloride), CAS [[1215711-91-3]]
Biozol Catalog Number:
MCE-HY-W587743
Supplier Catalog Number:
HY-W587743
Alternative Catalog Number:
MCE-HY-W587743-5MG,MCE-HY-W587743-10MG
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
AMK (hydrochloride)
N1-Acetyl-5-methoxykynuramine (AMK) hydrochloride is an active metabolite of the neurohormone melatonin (HY-B0075). N1-Acetyl-5-methoxykynuramine hydrochloride (200 µM) effectively scavenges singlet oxygen (ROS).1 It also inhibits the production of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) induced by epinephrine and arachidonic acid in a concentration- and time-dependent manner, and suppresses the increase in COX-2 levels induced by LPS (HY-D1056) in RAW 264.7 macrophages at a concentration of 500 µM. In a mouse model of Parkinsons disease induced by MPTP (HY-15608), N1-Acetyl-5-methoxykynuramine hydrochloride (20 mg/kg) reduces the increase in lipid peroxidation in the cytosol and mitochondria of the substantia nigra and striatum. N1-Acetyl-5-methoxykynuramine hydrochloride can be used in research on metabolic and neurological diseases[1][2][3][4][5][6]
Molecular Weight:
272.73
CAS Number:
[1215711-91-3]
Formula:
C12H17ClN2O3
Target:
COX,PGE synthase,Prostaglandin Receptor,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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