Dihydronicotinamide riboside is one of the precursors of NAD+ (HY-B0445) and mediates multiple signaling pathways. Dihydronicotinamide riboside increases NAD+ levels in cells and mitochondria, and maintains the survival of normal/neuronal cells under the action of NAD+-depleting genotoxins. In cancer cells, dihydronicotinamide riboside induces apoptosis, triggering ROS burst and mitochondrial dysfunction. In macrophages, dihydronicotinamide riboside activates the IKK-NF-kappaB pathway and induces the pro-inflammatory M1 phenotype[1][2][3].
Molekulargewicht:
256.26
Reinheit:
98
CAS Nummer:
[19132-12-8]
Formel:
C11H16N2O5
Target-Kategorie:
Apoptosis,Endogenous Metabolite,IKK,NF-kappaB,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
