Dihydronicotinamide riboside is one of the precursors of NAD+ (HY-B0445) and mediates multiple signaling pathways. Dihydronicotinamide riboside increases NAD+ levels in cells and mitochondria, and maintains the survival of normal/neuronal cells under the action of NAD+-depleting genotoxins. In cancer cells, dihydronicotinamide riboside induces apoptosis, triggering ROS burst and mitochondrial dysfunction. In macrophages, dihydronicotinamide riboside activates the IKK-NF-kappaB pathway and induces the pro-inflammatory M1 phenotype[1][2][3].
Molecular Weight:
256.26
Purity:
98
CAS Number:
[19132-12-8]
Formula:
C11H16N2O5
Target:
Apoptosis,Endogenous Metabolite,IKK,NF-kappaB,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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