Ouabagenin, aglycone precursor of Ouabain (HY-B1457), is a LXR ligand. Ouabagenin shows agonistic effect on the transactivation function of both LXRalpha and LXRbeta. Ouabagenin inhibits Na,K-ATPase ion pump activity with pH-dependent inhibitory. Ouabagenin downregulates ENaC subunit expression in renal cells and mouse kidney. Ouabagenin does not upregulate lipogenesis-related genes in liver cells or induce hepatic steatosis in mice[1][2].
Molekulargewicht:
438.51
CAS Nummer:
[508-52-1]
Formel:
C23H34O8
Target-Kategorie:
LXR,Na+/K+ ATPase
Anwendungsbeschreibung:
MCE Product type: Natural Products
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