O-Desmethylcarvedilol, CAS [[72956-44-6]]

Produktübersicht

• Artikelname: O-Desmethylcarvedilol, CAS [[72956-44-6]]
• Artikelnummer: MCE-HY-Z7733
• Hersteller Artikelnummer: HY-Z7733
• Alternativnummer: MCE-HY-Z7733-1UNIT,MCE-HY-Z7733-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: Desmethylcarvedilol, BM-14242

Produktbeschreibung

O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective beta-adrenergic receptor (beta-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 7.62 µM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 µg/kg, respectively)[1][2].

Produkteigenschaften

• Molekulargewicht: 392.45
• Reinheit: 97.4
• CAS Nummer: [72956-44-6]
• Formel: C23H24N2O4
• Target-Kategorie: Calcium Channel

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound