O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective beta-adrenergic receptor (beta-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 7.62 µM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 µg/kg, respectively)[1][2].
Molecular Weight:
392.45
Purity:
97.4
CAS Number:
[72956-44-6]
Formula:
C23H24N2O4
Target:
Calcium Channel
Application Notes:
Reference compound
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