AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol delta7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol delta7-delta8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3beta-ol[1][2][3]. Additionally, AY 9944 causes hypocholesterolemia and accumulation of 7DHC.
Molekulargewicht:
464.3
Reinheit:
97.08%
CAS Nummer:
[366-93-8]
Formel:
C22H30Cl4N2
Target-Kategorie:
Others
T14362
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten