AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol delta7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol delta7-delta8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3beta-ol[1][2][3]. Additionally, AY 9944 causes hypocholesterolemia and accumulation of 7DHC.
Molecular Weight:
464.3
Purity:
97.08%
CAS Number:
[366-93-8]
Formula:
C22H30Cl4N2
Target:
Others
T14362
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