BHPI is a potent inhibitor of nuclear estrogen receptor ERalpha-regulated gene expression that induces sustained ERalpha-dependent activation of the endoplasmic reticulum stress sensor and unfolded protein response, leading to persistent inhibition of protein synthesis, and in ERalpha-positive cancer cells it hyperactivates plasma membrane PLCgamma to generate IP3, deplete ER calcium stores via IP3R channels, and convert the normally protective UPR into a toxic response, making BHPI a valuable probe for estrogen signaling and ER stress-based cancer research.
Molekulargewicht:
331.36
Reinheit:
99.85%
CAS Nummer:
[56632-39-4]
Formel:
C21H17NO3
Target-Kategorie:
Estrogen/progestogen Receptor
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
