BHPI is a potent inhibitor of nuclear estrogen receptor ERalpha-regulated gene expression that induces sustained ERalpha-dependent activation of the endoplasmic reticulum stress sensor and unfolded protein response, leading to persistent inhibition of protein synthesis, and in ERalpha-positive cancer cells it hyperactivates plasma membrane PLCgamma to generate IP3, deplete ER calcium stores via IP3R channels, and convert the normally protective UPR into a toxic response, making BHPI a valuable probe for estrogen signaling and ER stress-based cancer research.
Molecular Weight:
331.36
Purity:
99.85%
CAS Number:
[56632-39-4]
Formula:
C21H17NO3
Target:
Estrogen/progestogen Receptor
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