SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 µM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 µM) and exhibits antiproliferative activity, inhibiting tumor growth.
Molekulargewicht:
482.96
CAS Nummer:
[1799802-29-1]
Formel:
C22H31ClN4O6
Target-Kategorie:
Akt|||HSP|||EGFR|||CDK
T200022
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
