SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 µM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 µM) and exhibits antiproliferative activity, inhibiting tumor growth.
Molecular Weight:
482.96
CAS Number:
[1799802-29-1]
Formula:
C22H31ClN4O6
Target:
Akt|||HSP|||EGFR|||CDK
T200022
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