Simufilamum Dihydrochloride Monohydrate, CAS [[2375909-85-4]] Preis auf Anfrage

Produktübersicht

• Artikelname: Simufilamum Dihydrochloride Monohydrate, CAS [[2375909-85-4]] Preis auf Anfrage
• Artikelnummer: TGM-T202428
• Hersteller Artikelnummer: T202428
• Alternativnummer: TGM-T202428-10MG,TGM-T202428-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: CJ368X8WT6 2HCl,H2O , Simufilam 2HCl,H2O

Produktbeschreibung

Simufilamum (also known as PTI-125) is an oral small-molecule compound candidate that targets altered conformations of filamin A. It binds and reverts the misfolded filamin A in the brains of Alzheimers disease patients, thereby slowing the diseases pathological progression. Additionally, PTI-125 reduces tau protein hyperphosphorylation, decreases Abeta42 aggregation and deposition, neurofibrillary tangles, and neuroinflammation. The compound demonstrates concentration-dependent efficacy in vitro, starting at 1 picomolar (pM), in both control groups and post-mortem hippocampal slices from Alzheimers disease (AD) patients. PTI-125 is the first therapeutic candidate to preferentially bind and reverse pathogenic protein conformations.

Produkteigenschaften

• Molekulargewicht: 350.28
• CAS Nummer: [2375909-85-4]
• Formel: C15H25Cl2N3O2

Bilder

T202428