Simufilamum Dihydrochloride Monohydrate, CAS [[2375909-85-4]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T202428
Supplier Catalog Number:
T202428
Alternative Catalog Number:
TGM-T202428-10MG,TGM-T202428-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
Alternative Names:
CJ368X8WT6 2HCl,H2O , Simufilam 2HCl,H2O
Simufilamum (also known as PTI-125) is an oral small-molecule compound candidate that targets altered conformations of filamin A. It binds and reverts the misfolded filamin A in the brains of Alzheimers disease patients, thereby slowing the diseases pathological progression. Additionally, PTI-125 reduces tau protein hyperphosphorylation, decreases Abeta42 aggregation and deposition, neurofibrillary tangles, and neuroinflammation. The compound demonstrates concentration-dependent efficacy in vitro, starting at 1 picomolar (pM), in both control groups and post-mortem hippocampal slices from Alzheimers disease (AD) patients. PTI-125 is the first therapeutic candidate to preferentially bind and reverse pathogenic protein conformations.
Molecular Weight:
350.28
CAS Number:
[2375909-85-4]
Formula:
C15H25Cl2N3O2
T202428
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