LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.
Molekulargewicht:
518.53
CAS Nummer:
[2920000-23-1]
Formel:
C27H29F3N2O5
Target-Kategorie:
FXR
T203062
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