(rac)-Talazoparib, CAS [[1207454-56-5]] Preis auf Anfrage

Produktübersicht

• Artikelname: (rac)-Talazoparib, CAS [[1207454-56-5]] Preis auf Anfrage
• Artikelnummer: TGM-T204239
• Hersteller Artikelnummer: T204239
• Alternativnummer: TGM-T204239-10MG,TGM-T204239-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: (rac)-BMN-673 , (rac)-LT-673 , (rac)-Talazoparib

Produktbeschreibung

(rac)-Talazoparib ((rac)-BMN-673) (Compound 47) is an orally active inhibitor of PARP1/2, with Ki values of 1.2 nM and 0.87 nM, respectively. It inhibits cellular PARylation at an EC50 of 2.51 nM. This compound leads to the accumulation of DNA damage and suppresses the proliferation of BRCA1/2-mutated MX-1 and Capan-1 cells, with IC50 values of 0.3 nM and 5 nM, respectively. Additionally, (rac)-Talazoparib exhibits antitumor activity in mouse models.

Produkteigenschaften

• Molekulargewicht: 380.351
• CAS Nummer: [1207454-56-5]
• Formel: C19H14F2N6O
• Target-Kategorie: PARP

Bilder

T204239