(rac)-Talazoparib, CAS [[1207454-56-5]] Preis auf Anfrage

Product Overview

• Article Name: (rac)-Talazoparib, CAS [[1207454-56-5]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T204239
• Supplier Catalog Number: T204239
• Alternative Catalog Number: TGM-T204239-10MG,TGM-T204239-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: (rac)-BMN-673 , (rac)-LT-673 , (rac)-Talazoparib

Product Description

(rac)-Talazoparib ((rac)-BMN-673) (Compound 47) is an orally active inhibitor of PARP1/2, with Ki values of 1.2 nM and 0.87 nM, respectively. It inhibits cellular PARylation at an EC50 of 2.51 nM. This compound leads to the accumulation of DNA damage and suppresses the proliferation of BRCA1/2-mutated MX-1 and Capan-1 cells, with IC50 values of 0.3 nM and 5 nM, respectively. Additionally, (rac)-Talazoparib exhibits antitumor activity in mouse models.

Product Properties

• Molecular Weight: 380.351
• CAS Number: [1207454-56-5]
• Formula: C19H14F2N6O
• Target: PARP

Images

T204239