PROTAC AR Degrader-8, CAS [[3044108-04-2]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC AR Degrader-8, CAS [[3044108-04-2]] Preis auf Anfrage
• Artikelnummer: TGM-T204324
• Hersteller Artikelnummer: T204324
• Alternativnummer: TGM-T204324-10MG,TGM-T204324-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC AR Degrader-8 (Compound NP18) functions as a PROTAC degrader targeting the androgen receptor (AR) and effectively degrades AR-FL in both 22Rv1 and LNCaP cells with DC50 values of 0.018 µM and 0.14 µM, respectively. It also degrades AR-V7 in 22Rv1 cells with a DC50 of 0.026 µM. Additionally, PROTAC AR Degrader-8 inhibits the proliferation of 22Rv1 and LNCaP cancer cells, exhibiting IC50 values of 0.038 µM and 1.11 µM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in 22Rv1 cells (apoptosis). Demonstrating anticancer efficacy, PROTAC AR Degrader-8 shows activity in both mouse and zebrafish models. [Pink: ligand for target protein AR ligand-33, Black: linker, Blue: ligand for E3 ligase Cereblon]

Produkteigenschaften

• Molekulargewicht: 703.783
• CAS Nummer: [3044108-04-2]
• Formel: C40H41N5O7
• Target-Kategorie: PROTACs|||Apoptosis|||Androgen Receptor

Bilder

T204324