PROTAC AR Degrader-8, CAS [[3044108-04-2]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T204324
Supplier Catalog Number:
T204324
Alternative Catalog Number:
TGM-T204324-10MG,TGM-T204324-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
PROTAC AR Degrader-8 (Compound NP18) functions as a PROTAC degrader targeting the androgen receptor (AR) and effectively degrades AR-FL in both 22Rv1 and LNCaP cells with DC50 values of 0.018 µM and 0.14 µM, respectively. It also degrades AR-V7 in 22Rv1 cells with a DC50 of 0.026 µM. Additionally, PROTAC AR Degrader-8 inhibits the proliferation of 22Rv1 and LNCaP cancer cells, exhibiting IC50 values of 0.038 µM and 1.11 µM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in 22Rv1 cells (apoptosis). Demonstrating anticancer efficacy, PROTAC AR Degrader-8 shows activity in both mouse and zebrafish models. [Pink: ligand for target protein AR ligand-33, Black: linker, Blue: ligand for E3 ligase Cereblon]
Molecular Weight:
703.783
CAS Number:
[3044108-04-2]
Formula:
C40H41N5O7
Target:
PROTACs|||Apoptosis|||Androgen Receptor
T204324
* VAT and and shipping costs not included. Errors and price changes excepted
