PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-beta1 and beta-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38, Black: linker, Blue: ligand for E3 ligase Cereblon]
Molekulargewicht:
765.339
Formel:
C43H49ClN6O5
Target-Kategorie:
Androgen Receptor|||PROTACs
T204370
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
