PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-beta1 and beta-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38, Black: linker, Blue: ligand for E3 ligase Cereblon]
Molecular Weight:
765.339
Formula:
C43H49ClN6O5
Target:
Androgen Receptor|||PROTACs
T204370
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