PKZ18 is an antibiotic that inhibits bacterial growth with minimum inhibitory concentrations of 32-64 µg/mL against most Gram-positive bacteria, acting by suppressing in vivo transcription and translation of glycyl-tRNA synthetase mRNA, selectively targeting stem I specifier loops in Gram-positive organisms, reducing T-box transcriptional read-through, disrupting codon-anticodon recognition required for tRNA binding, and demonstrating a mechanism that is refractory to conventional resistance development.
Molekulargewicht:
398.52
Reinheit:
98.08%
CAS Nummer:
[849658-87-3]
Formel:
C22H26N2O3S
Target-Kategorie:
Antibiotic
T204863
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
