PKZ18 is an antibiotic that inhibits bacterial growth with minimum inhibitory concentrations of 32-64 µg/mL against most Gram-positive bacteria, acting by suppressing in vivo transcription and translation of glycyl-tRNA synthetase mRNA, selectively targeting stem I specifier loops in Gram-positive organisms, reducing T-box transcriptional read-through, disrupting codon-anticodon recognition required for tRNA binding, and demonstrating a mechanism that is refractory to conventional resistance development.
Molecular Weight:
398.52
Purity:
98.08%
CAS Number:
[849658-87-3]
Formula:
C22H26N2O3S
Target:
Antibiotic
T204863
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